Bicarbonate- versus lactate-buffered solutions for hemodiafiltration in acute renal failure: a meta-analysis

doi:10.3969/j.issn.2095-4344.2014.39.005

Abstract

Abstract:

BACKGROUND: Hemodialysis therapy is an important means for the treatment of acute renal failure, which aims to remove excess water and toxins and maintain acid-base balance of a patient, creating conditions for medication and nutrition therapy while avoiding multiple organ failure.

OBJECTIVE: To compare bicarbonate- and lactate-buffered solutions for acute continuous hemodiafiltration in acute renal failure.

METHODS: A computer-based search was performed in PubMed, EMBASE, SCI, Cochrane Library, Chinese Biomedical Literature Database, China Journal Full Text Database, Chinese Medical Association Journals for randomized control trials related to bicarbonate- versus lactate-buffered solutions for hemodiafiltration in acute renal failure published before January 2014. The quality of the included studies was evaluated by Cochrane Handbook, and data were analyzed by RevMan 5.1 from the Cochrane Collaboration.

RESULTS AND CONCLUSION: Four studies (171 patients) met inclusion criteria. Overall, patients treated with bicarbonate-buffered solutions had fewer cardiovascular complications and symptomatic hypotension events as well as lower serum lactate levels than patients who received lactate-buffered solutions (P < 0.05). There were no differences in mortality, serum bicarbonate levels, serum creatinine, serum pH, carbon dioxide partial pressure.The current evidence shows that patients undergoing bicarbonate-buffered solutions may experience fewer cardiovascular complications and symptomatic hypotension. Given the limited research, it is insufficient to recommend for clinical use.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: bicarbonates, lactates, renal dialysis, meta-analysis

CLC Number:

R318

Wanyan Ping-ping, Wang Xiao-ling, Wang Wen-ge, Wang Jian-qin. Bicarbonate- versus lactate-buffered solutions for hemodiafiltration in acute renal failure: a meta-analysis[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(39): 6258-6264.

Figures/Tables 10

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